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MABS186 Anti-LOX-1, clone 9E12.1

Anti-LOX-1 Antibody, clone 9E12.1 is an antibody against LOX-1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).

Anti-LOX-1, clone 9E12.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: OLR1, CLEC8A, LOX1 UniProt Number: P78380
MABS186
100 µg  
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Speciální nabídky

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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS186
DescriptionAnti-LOX-1, clone 9E12.1
Alternate Names
  • LOX-1
  • Oxidized low-density lipoprotein receptor 1
  • Ox-LDL receptor 1
  • C-type lectin domain family 8 member A
  • Lectin-like oxidized LDL receptor 1
  • Lectin-like oxLDL receptor 1
  • hLOX-1
  • Lectin-type oxidized LDL receptor 1
  • Oxidized low-density lipoprotein receptor 1, soluble form
Background InformationLOX1 is a plasma membrane receptor, that also has a free soluble receptor form, that is the receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. LOX1 is also the receptor for HSP70, and LOX1 acts as a leukocyte adhesion molecule on glycosylated proteins present on platelets, monocytes, bacteria, apoptotic cells in inflammatory responses.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-LOX-1 Antibody, clone 9E12.1 is an antibody against LOX-1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LOX-1 in human placenta tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human LOX-1.
Clone9E12.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • OLR1
  • CLEC8A
  • LOX1
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~35 kDa observed. The calculated molecular weight of this protein is 31 kDa, but can be observed at ~33-37 kDa due to high glycosylation.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in KG-1 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected LOX-1 in 200 µg of KG-1 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
MABS186 04055977135367

Documentation

Anti-LOX-1, clone 9E12.1 MSDS

Title

Safety Data Sheet (SDS) 

Anti-LOX-1, clone 9E12.1 Certificates of Analysis

TitleLot Number
Anti-LOX-1, clone 9E12.1 - 3191404 3191404
Anti-LOX-1, clone 9E12.1 - 3532303 3532303
Anti-LOX-1, clone 9E12.1 - 3670610 3670610
Anti-LOX-1, clone 9E12.1 - 3923043 3923043
Anti-LOX-1, clone 9E12.1 - 4070063 4070063
Anti-LOX-1, clone 9E12.1 -2892459 2892459
Anti-LOX-1, clone 9E12.1 -Q2550834 Q2550834
Anti-LOX-1, clone 9E12.1 Monoclonal Antibody 3030539
Anti-LOX-1, clone 9E12.1 Monoclonal Antibody 2872172
Anti-LOX-1, clone 9E12.1 Monoclonal Antibody 3768033
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Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.