ks	Katalogové číslo	Popis objednávky	ks/bal.	Cena podle ceníku
			96-Well Plate

ks	Katalogové číslo	Popis objednávky	ks/bal.	Cena podle ceníku
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

ABT259 Sigma-AldrichAnti-Fibrinogen gamma chain Antibody

Anti-Fibrinogen gamma chain Antibody is an antibody against Fibrinogen gamma chain for use in Immunohistochemistry and Immunocytochemistry.

Anti-Fibrinogen gamma chain Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

CoA
References
Technical Information

Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: Fgg UniProt Number: Q8VCM7

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Replacement Information

Speciální nabídky

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Tabulka spec. kláve

Species Reactivity	Key Applications	Host	Format	Antibody Type
M, H	WB, IHC	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABT259
Description	Anti-Fibrinogen gamma chain Antibody
Alternate Names	Fibrinogen gamma chain
Background Information	The gamma component of fibrinogen is a glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Various cleavage fragments of fibrinogen and fibrin also regulate cell adhesion, vasoconstricting, chemotaxis, and mitosis. Disorders caused by gamma chain mutations include dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants, the common gammaA and the less abundant gamma'.

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ300

Applications
Application	Anti-Fibrinogen gamma chain Antibody is an antibody against Fibrinogen gamma chain for use in Immunohistochemistry and Immunocytochemistry.
Key Applications	Western Blotting Immunohistochemistry
Application Notes	Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Fibrinogen gamma chain in mouse kidney and mouse liver tissue.

Biological Information
Immunogen	KLH-conjugated linear peptide corresponding to the fibrinogen C-terminal domain of mouse Fibrinogen gamma chain.
Epitope	Fibrinogen C-terminal Domain
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Species Reactivity	Mouse Human
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_598623
Gene Symbol	Fgg
Purification Method	Affinity Purfied
UniProt Number	Q8VCM7
Molecular Weight	~55 kDa observed. The calculated molecular weight is 49 kDa, however Fibrinogen gamma chain has been shown as a ~55 kDa band due to glycosylation (Nickerson, J.M., et al. (1981). Biochemistry. 20:2818-2821).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in mouse liver tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected Fibrinogen gamma chain in 10 µg of mouse liver tissue lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Katalogové číslo	GTIN
ABT259	04055977136326

Documentation

Anti-Fibrinogen gamma chain Antibody Certificates of Analysis

Title	Lot Number
Anti-Fibrinogen gamma chain - 3249413	3249413
Anti-Fibrinogen gamma chain - 3397943	3397943
Anti-Fibrinogen gamma chain -Q2556980	Q2556980

References

Reference overview	Pub Med ID
Biochemistry Nickerson, JM; Fuller, GM Biochemistry 20 2818-21 1981 Zobrazit abstrakt Specific immunoprecipitation and affinity chromatography on Con A-Sepharose of in vitro translated products derived from rat liver messenger ribonucleic acid (mRNA), total polysomes, and rough microsomes have been used to determine temporal events of glycosylation of the subunits of fibrinogen. The A alpha chain is not glycosylated, whereas both the B beta and the gamma chains have carbohydrate clusters (probably Asn linked). Evidence presented here shows that the gamma chain receives its core carbohydrate as an early cotranslational event. The B beta chain is glycosylated later and likely is glycosylated at the time of polypeptide termination or shortly after it is released from the ribosome into the cisternal space of the rough endoplasmic reticulum.	7248249

Reference overview

Pub Med ID

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.

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Kategorie

Life Science Research > Antibodies and Assays > Primary Antibodies

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