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ABF118 Anti-FPR2 Antibody

Anti-FPR2 Antibody | ABF118 is an antibody against FPR2 Antibody for use in Western Blotting, Flow Cytometry.

Anti-FPR2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: FPR2, FPRH1, FPRL1, LXA4R UniProt Number: P25090
ABF118
100 µg  
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Speciální nabídky

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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, FCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABF118
DescriptionAnti-FPR2 Antibody
Alternate Names
  • N-formyl peptide receptor 2
  • FMLP-related receptor I
  • FMLP-R-I
  • Formyl peptide receptor-like 1
  • HM63
  • Lipoxin A4 receptor
  • LXA4 receptor
  • RFP
  • FPR2
Background InformationFormyl peptide receptors (FPRs) are G protein coupled receptors critical for our immune response and the cellular activation and or suppression of immune cell activities. N-formyl peptides are produced by the degradation of either bacteria or host cells and serve as chemoattractant agents for white blood cells. There are three known formyl peptide receptors, FPR1, FPR2, and FPR3 all appear to have similar functions. Binding of N-formyl peptides activates neutrophils via the phosphatidylinositol-calcium second messenger system. In some cases binding leads to a down regulation of immune signals such as in the down regulation observed against the proinflammatory signaling agent leukotriene B4. Interestingly, FPRs also have endogenous ligands which appear to function in a developmental fashion and not directly as an immune function. For instance, FPR2’s endogenous ligand is a peptide named Cathelin-related antimicrobial peptide (CRAMP) which is critical for proper dendritic cell maturation. FRP2 is abundantly expressed in the lung, spleen and testis neutrophils. Because of their role in the immune cell activation, FPRs are also being investigated as possible targets for modulating immune caused diseases such as arthritis.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-FPR2 Antibody | ABF118 is an antibody against FPR2 Antibody for use in Western Blotting, Flow Cytometry.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application NotesFlow Cytometry Analysis: 1.0 µg of this antibody detected FPR2 in HL-60 cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human FPR2.
Epitopeextracellular domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • FPR2
  • FPRH1
  • FPRL1
  • LXA4R
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~45 kDa observed. The calculated molecular weight of this protein is 39 kDa, but can be observed at ~45 kDa due to high glycosylation.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HL-60 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected FPR2 in 10 µg of HL-60 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
ABF118 04055977123777