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ABN1024 Anti-BMP-9 (GDF-2)

Anti-BMP-9 (GDF-2), Cat. No. ABN1024, is a highly specific rabbit polyclonal antibody that targets Bone morphogenetic protein 9 (Growth/differentiation factor 2) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-BMP-9 (GDF-2) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: BMP9, GDF2 UniProt Number: Q9UK05
ABN1024
200 µL  
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Replacement Information

Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN1024
DescriptionAnti-BMP-9 (GDF-2)
Alternate Names
  • Bone morphogenetic protein 9
  • Growth/differentiation factor 2
Background InformationGrowth/differentiation factor 2 (UniPort: Q9UK05; also known as GDF-2, Bone morphogenetic protein 9, BMP-9) is encoded by the GDF2 (also known as BMP9) gene (Gene ID: 2658) in human. BMP-9 is a member of the TGF-beta family that forms a signaling complex with two type 1 and two type II receptors. It is synthesized with a signal peptide of (aa 1-22) and a propeptide (aa 22-319). The signal peptide is cleaved in the mature protein. The propeptide of BMP-9 does not interfere with the biological activity of BMP-9 and is believed to remain associated with the mature peptide. BMP9 is constitutively secreted from the liver in an active form into the circulation. BMP-9 signals through high affinity activing receptor-like kinase 1 (ALK1) in endothelial cells and maintains endothelial homeostasis. It is also considered as a potent osteogenic signaling factor in mesenchymal stem cells. BMP-9 is also known to induce an increase in collagen, fibronectin, and connective tissue growth factor expression associated with Smad 1/5/8, Smad 2/3, and Erk1/2 activation. It is also reported to promote the acquisition of the cholinergic phenotype in basal forebrain cholinergic neurons during development and protects these neurons. Defects in BMP9 gene are known to cause Telangiectasia, hereditary hemorrhagic disease that leads to vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera and causes recurrent epistaxis and gastro-intestinal hemorrhage (Ref.: Wei, Z et al. (2014). J. Biol. Chem. 289 (45); 31150 31159; Munoz-Felix, JM et al. (2016). Cell Signal 28(9): 1252-1261).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine, 0.15 M NaCl, pH7.4 with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-BMP-9 (GDF-2), Cat. No. ABN1024, is a highly specific rabbit polyclonal antibody that targets Bone morphogenetic protein 9 (Growth/differentiation factor 2) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BMP-9 (GDF-2) in human liver and human liver cancer tissues.
Biological Information
ImmunogenGST-tagged recombinant fragment corresponding to 110 amino acids from the C-terminal region of human Bone morphogenetic protein 9 (BMP-9).
EpitopeC-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects human Bone morphogenetic protein 9 (BMP-9). It targets an epitope within 110 amino acids from the C-terminal region.
IsotypeIgG
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • BMP9
  • GDF2
Purification MethodAffinity Purified
UniProt Number
Molecular Weight~45 kDa observed; 47.32 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected BMP-9 (GDF-2) in 10 µg of human liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
ABN1024 04054839352560