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MABT1352-100UG Anti-Aquaporin 11 Antibody, clone 8H9

Anti-Aquaporin 11, clone 8H9, Cat. No. MABT1352, is a highly specific mouse monoclonal antibody that targets Aquaporin-11 and has been tested for use in Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting.

MABT1352-100UG
100 μg  
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Description
Catalogue NumberMABT1352-100UG
DescriptionAnti-Aquaporin 11 Antibody, clone 8H9
Alternate Names
  • AQP-11
Background InformationAquaporin-11 (UniProt: Q8NBQ7; also known as AQP-11) is encoded by the AQP11 (also known as AQPX1) gene (Gene ID: 282679) in human. Aquaporins are a family of 13 integral membrane proteins that are essential for water transport across membranes. AQP-11 is a multi-pass membrane protein that displays several unique features. Human AQP-11 displays high degree of homology with mouse, rat and horse AQP-11. The water permeability of AQP-11 is shown to be about 8-fold lower than AQP-1 and it is reversibly inhibited by mercury ions. It is shown to be involved in slow, but constant water movement across the membrane. AQP-11 shares two tandem repeats with other aquaporins, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA; aa 99-101 and 216-218). However, the first tandem repeat of AQP-11 contains cysteine instead of alanine. AQP-11 is detected in photoreceptor cells and it shown to be down-regulated in retina in cases of uveitis. Clone 8H9 exhibits binding to a conserved linear epitope of mammalian AQP-11. (Ref.: Amann, B., et al. (2016). Int. J. Mol. Sci,17(7): 1145; Yakata, K., et al. (2011). J. Struct. Biol. 174(2); 315-320).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-Aquaporin 11, clone 8H9, Cat. No. MABT1352, is a highly specific mouse monoclonal antibody that targets Aquaporin-11 and has been tested for use in Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Immunoprecipitation
  • Western Blotting
Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:50 dilution from a representative lot detected Aquaporin-11 in mouse retina tissue sections.

Immunoprecipitation Analysis: A representative immunoprecipitated Aquaporin-11 in Immunoprecipitation applications (Deeg, C.A., et. al. (2016). J Neuroinflammation. 13(1):89).

Immunohistochemistry Analysis: A representative lot detected Aquaporin-11 in Immunohistochemistry applications (Deeg, C.A., et. al. (2016). J Neuroinflammation. 13(1):89).

Immunohistochemistry (Paraffin) Analysis: A representative lot detected Aquaporin-11 in Immunohistochemistry applications (Amann, B., et. al. (2016). Int J Mol Sci. 17(7)).

Western Blotting Analysis: A representative lot detected Aquaporin-11 in Western Blotting applications (Deeg, C.A., et. al. (2016). J Neuroinflammation. 13(1):89).
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 12 amino acids from the C-terminal region of human Aquaporin-11.
Clone8H9
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 8H9 specifically detects Aquaporin-11 in multiple species. It targets an epitope with in 12 amino acids from the C-terminal region.
IsotypeIgG1κ
Species Reactivity
  • Mouse
  • Horse
  • Human
  • Rat
Species Reactivity NoteHuman, Horse, Mouse, Rat.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • AQP11
  • AQPX1
Purification MethodProtein G purified
UniProt Number
Molecular Weight30.20 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human retina tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected Aquaporin-11 in human retina tissue sections.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
MABT1352-100UG 04054839659942