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ABE302 Anti-ATDC Antibody

Anti-ATDC Antibody is a Rabbit Polyclonal Antibody for detection of ATDC also known as Ataxia telangiectasia group D-associated protein & has been validated in WB & IP.

Anti-ATDC Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: TRIM29, ATDC UniProt Number: Q14134
ABE302
100 µg  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IPRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE302
DescriptionAnti-ATDC Antibody
Alternate Names
  • Ataxia telangiectasia group D-associated protein
  • tripartite motif containing protein 29
Background InformationAtaxia telangiectasia group D-complementing (ATDC) protein, also known as tripartite motif containing protein 29 (TRIM29), belongs to the TRIM protein family. Studies have shown that ATDC may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. The ATDC gene is located at 11q23 where loss of heterozygosity has been observed in many kinds of cancers; underexpression of ATDC has been reported in breast and prostate cancer. ATDC may also complement the radiosensitivity defect of ataxia telangiectasia phenotype.
References
Product Information
FormatAffinity Purified
Control
  • RAW 264.7 cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-ATDC Antibody is a Rabbit Polyclonal Antibody for detection of ATDC also known as Ataxia telangiectasia group D-associated protein & has been validated in WB & IP.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Application NotesImmunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Yuan, Z., et al. (2010). J Biol Chem. 285(50):39329-39338.)
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to a region within amino acides 565 to 595 of human ATDC .
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008].
Gene Symbol
  • TRIM29
  • ATDC
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line.

SUBUNIT STRUCTURE: Interacts with VIM and HINT1.

SUBCELLULAR LOCATION: Cytoplasm. Note: Colocalizes with intermediate filaments.

TISSUE SPECIFICITY: Expressed in placenta, prostate and thymus.

PTM: Constitutively phosphorylated by PKC on serine/threonine in A431 cells.

SEQUENCE SIMILARITIES: Contains 1 B box-type zinc finger.
Molecular Weight~66 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in RAW 264.7 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected ATDC on 10 µg of RAW 264.7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
ABE302 04053252633942