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07-546 Anti-ADAP/SLAP-130/Fyb Antibody

07-546
200 µg  
Purchase on Sigma-Aldrich

Speciální nabídky

Přehled

Speciální nabídky

Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWB, IPRbPurifiedPolyclonal Antibody
Description
Catalogue Number07-546
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-ADAP/SLAP-130/Fyb Antibody
Product Information
FormatPurified
Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Quality LevelMQ100
Applications
ApplicationAnti-ADAP/SLAP-130/Fyb Antibody is an antibody against ADAP/SLAP-130/Fyb for use in WB & IP.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Biological Information
Immunogensynthetic peptide corresponding to amino acids 755-768 of mouse Fyn binding protein (ADAP/SLAP-130/Fyb)
HostRabbit
SpecificityADAP/SLAP-130/Fyb
IsotypeIgG
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • FYB
  • SLAP130
  • FYB-120/130
  • p120/p130
  • PRO0823
  • ADAP
  • SLAP-130
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O15117 # Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.
SIZE: 783 amino acids; 85421 Da
SUBUNIT: Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity).
TISSUE SPECIFICITY: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
PTM: T-cell receptor ligation leads to increased tyrosine phosphorylation.
SIMILARITY: SwissProt: O15117 ## Contains 1 SH3 domain.
Molecular Weight130kDa
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot in RIPA lysates from RAW 264.7 macrophage cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size200 µg
Global Trade Item Number
Katalogové číslo GTIN
07-546 04053252670336