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155100 Aminogenistein

Aminogenistein MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4ʹ-Amino-6-hydroxyflavone

155100
  
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Přehled

Replacement Information
Description
OverviewInhibits protein-tyrosine kinase activity of p56lck (IC50 = 1.2 µM).
Catalogue Number155100
Brand Family Calbiochem®
Synonyms4ʹ-Amino-6-hydroxyflavone
References
ReferencesCushman, M., et al. 1991. J. Med. Chem. 34, 798.
Product Information
CAS number132018-32-7
FormSolid
Hill FormulaC₁₅H₁₁NO₃
Chemical formulaC₁₅H₁₁NO₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetp56lck
Primary Target IC<sub>50</sub>1.2 µM
Purity>95% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
155100 0

Documentation

Aminogenistein Certificates of Analysis

TitleLot Number
155100

References

Přehled odkazů
Cushman, M., et al. 1991. J. Med. Chem. 34, 798.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms4ʹ-Amino-6-hydroxyflavone
DescriptionInhibits protein-tyrosine kinase activity of p56lck (IC50 = 1.2 µM). p56lck is a 56 kDa enzyme that exhibits considerable sequence homology to pp60src and other members of the src family of tyrosine kinases. The expression of p56lck is normally restricted to lymphoid cells, primarily those of the T cell lineage. p56lck is thought to play a role in mediating signal transduction via the CD4 receptor during lymphocyte activation. The presence of a 4'-amino and a 6-hydroxyl group on 4'-amino-6-hydroxyflavone promotes high affinity interactions with p56lck, decreasing p56lck interactions with protein-serine/threonine kinases.
FormSolid
CAS number132018-32-7
Chemical formulaC₁₅H₁₁NO₃
Structure formulaStructure formula
Purity>95% by NMR
SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesCushman, M., et al. 1991. J. Med. Chem. 34, 798.