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504745 AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem

AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride

Primary Target: mGlu₇ receptors
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Tabulka spec. kláve

CAS #Empirical Formula
97075-46-2C₂₈H₂₈N₂ • 2HCl
Description
Overview

This product has been discontinued.



A potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinsons disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
Catalogue Number504745
Brand Family Calbiochem®
SynonymsN,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride
References
ReferencesCavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
Product Information
CAS number97075-46-2
FormWhite solid
Hill FormulaC₂₈H₂₈N₂ • 2HCl
Chemical formulaC₂₈H₂₈N₂ • 2HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetmGlu₇ receptors
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
504745 0

Documentation

AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Cavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2013 JSW
SynonymsN,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride
DescriptionA potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinsons disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
FormWhite solid
CAS number97075-46-2
Chemical formulaC₂₈H₂₈N₂ • 2HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.