Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

658404 AG 555

AG 555 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide, Tyrphostin B46

658404
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information
Description
Overview

This product has been discontinued.

Please refer to our complete listing of receptor tyrosine kinase inhibitors for possible alternatives. Please read all alternative product documentation carefully and contact technical service if you need additional information.





A potent inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 700 nM). Exhibits opposite potency profiles with AG 527 (Cat. No. 658402) for EGF receptor autophosphorylation versus poly-GAT substrate phosphorylation.
Catalogue Number658404
Brand Family Calbiochem®
Synonymsα-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide, Tyrphostin B46
References
ReferencesRovin, B.H., and Tan, L.C. 1994. Kidney Int. 46, 1059. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Product Information
FormYellow solid
Hill FormulaC₁₉H₁₈N₂O₃
Chemical formulaC₁₉H₁₈N₂O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetepidermal growth factor (EGF) receptor kinase autophosphorylation
Primary Target IC<sub>50</sub>700 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
658404 0

Documentation

AG 555 Certificates of Analysis

TitleLot Number
658404

References

Přehled odkazů
Rovin, B.H., and Tan, L.C. 1994. Kidney Int. 46, 1059. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-September-2008 RFH
Synonymsα-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide, Tyrphostin B46
DescriptionA potent inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 700 nM). Exhibits opposite potency profiles with Tyrphostin B44(-) (Cat. No. 658402) for EGF receptor autophosphorylation versus poly-GAT substrate phosphorylation.
FormYellow solid
Chemical formulaC₁₉H₁₈N₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO or ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesRovin, B.H., and Tan, L.C. 1994. Kidney Int. 46, 1059. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.