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658402 AG 527

AG 527 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)

658402
  
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Description
OverviewA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 2.5 µM). Also inhibits phosphorylation of poly-GAT by the EGF receptor (IC50 = 400 nM).
Catalogue Number658402
Brand Family Calbiochem®
Synonyms(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)
References
ReferencesGazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Product Information
CAS number133550-32-0
FormYellow solid
Hill FormulaC₁₈H₁₆N₂O₃
Chemical formulaC₁₈H₁₆N₂O₃
Structure formula ImageStructure formula Image
Biological Information
Primary Targetepidermal growth factor (EGF) receptor kinase autophosphorylation
Primary Target IC<sub>50</sub>2.5 µM
Secondary targetphosphorylation of poly-GAT by the EGF receptor (IC₅₀ = 400 nM)
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Global Trade Item Number
Katalogové číslo GTIN
658402 0