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658550 AG 1295 - CAS 71897-07-9 - Calbiochem

A cell-permeable, reversible, ATP-competitive, and selective inhibitor of platelet-derived growth factor (PDGF) receptor kinase (IC₅₀ = 500 nM) and PDGF-dependent DNA synthesis (IC₅₀ = 2.5 µM) in Swiss/3T3 cells.

AG 1295 - CAS 71897-07-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6,7-Dimethyl-2-phenylquinoxaline

Primary Target: PDGFR kinase
658550
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
71897-07-9C₁₆H₁₄N₂

Products

Katalogové čísloBalení ks/bal.
658550-5MG Plastová ampulka 5 mg
Description
OverviewA cell-permeable, reversible, ATP-competitive, and selective inhibitor of platelet-derived growth factor (PDGF) receptor kinase (IC50 = 500 nM) and PDGF-dependent DNA synthesis (IC50 = 2.5 µM) in Swiss/3T3 cells. Has no effect on EGF receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis. A potent blocker of smooth muscle cell proliferation.
Catalogue Number658550
Brand Family Calbiochem®
Synonyms6,7-Dimethyl-2-phenylquinoxaline
References
ReferencesBanai, S., et al. 1998. Circulation 97, 1960.
Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
Kovalenko, M., et al. 1994. Cancer Res. 54, 6106.
Product Information
CAS number71897-07-9
ATP CompetitiveY
FormWhite to yellow solid
Hill FormulaC₁₆H₁₄N₂
Chemical formulaC₁₆H₁₄N₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPDGFR kinase
Primary Target IC<sub>50</sub>500 nM against PDGFR kinase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
658550-5MG 07790788052225

Documentation

AG 1295 - CAS 71897-07-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

AG 1295 - CAS 71897-07-9 - Calbiochem Certificates of Analysis

TitleLot Number
658550

References

Přehled odkazů
Banai, S., et al. 1998. Circulation 97, 1960.
Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
Kovalenko, M., et al. 1994. Cancer Res. 54, 6106.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-September-2020 JSW
Synonyms6,7-Dimethyl-2-phenylquinoxaline
DescriptionSelectively inhibits platelet-derived growth factor (PDGF) receptor kinase (IC50 = 500 nM) and the PDGF-dependent DNA synthesis (IC50 = 2.5 µM) in Swiss 3T3 cells. Has no effect on epidermal growth factor (EGF) receptor autophosphorylation and shows only a weak effect on EGF- or insulin-stimulated DNA synthesis.
FormWhite to yellow solid
CAS number71897-07-9
Chemical formulaC₁₆H₁₄N₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or CH₂Cl₂
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesBanai, S., et al. 1998. Circulation 97, 1960.
Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
Kovalenko, M., et al. 1994. Cancer Res. 54, 6106.