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114810 ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem

ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor

Primary Target: ADAMTS-5
114810
  
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Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
929634-33-3C₁₆H₁₁ClF₃N₃OS₃
Description
Overview

This product has been discontinued.



A thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
Catalogue Number114810
Brand Family Calbiochem®
Synonyms5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor
References
ReferencesBursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
Product Information
CAS number929634-33-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₆H₁₁ClF₃N₃OS₃
Chemical formulaC₁₆H₁₁ClF₃N₃OS₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetADAMTS-5
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22-36/37/38

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 36/37

Wear suitable protective clothing and gloves.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
114810 0

Documentation

ADAMTS-5 Inhibitor - CAS 929634-33-3 - Calbiochem Certificates of Analysis

TitleLot Number
114810

References

Přehled odkazů
Bursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
Synonyms5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one, Aggrecanase-2 Inhibitor
DescriptionA thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number929634-33-3
Chemical formulaC₁₆H₁₁ClF₃N₃OS₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesBursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185.
Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.