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565783 β-Secretase Substrate VIII, Fluorogenic

β-Secretase Substrate VIII, Fluorogenic MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: JMV2236, Abz-VNL~DAE-EDDnp

565783
  
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Replacement Information
Description
OverviewAn internally quenched fluorogenic peptide substrate designed from Swedish mutated β-APP (β-amyloid precursor protein) sequence that specifically detects the activity of BACE1 (β-secretase 1) and BACE2, but not that of cathepsin-D, ADAM-10, TACE, PS1, or PS2. Cleavage occurs between Leu-Asp residues, which results in fluorescence enhancement. Also useful for screening of inhibitors for BACE1 & BACE2.
Catalogue Number565783
Brand Family Calbiochem®
SynonymsJMV2236, Abz-VNL~DAE-EDDnp
References
ReferencesAndrau, D., et al. 2003. J. Biol. Chem. 278, 25859.
Product Information
FormLyophilized yellow solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₂H₅₈N₁₂O₁₆
Chemical formulaC₄₂H₅₈N₁₂O₁₆
Hygroscopic Hygroscopic
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Peptide SequenceAbz-Val-Asn-Leu~Asp-Ala-Glu-EDDnp
Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
565783 0

Documentation

β-Secretase Substrate VIII, Fluorogenic Certificates of Analysis

TitleLot Number
565783

References

Přehled odkazů
Andrau, D., et al. 2003. J. Biol. Chem. 278, 25859.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-October-2008 JSW
SynonymsJMV2236, Abz-VNL~DAE-EDDnp
DescriptionAn internally quenched fluorogenic peptide substrate designed from the Swedish mutant β-APP (β-amyloid precursor protein) sequence that specifically detects the activity of BACE1 (β-secretase 1) and BACE2, but not that of cathepsin-D, ADAM10, TACE, PS1, or PS2. Cleavage occurs at the Leu-Asp bond resulting in enhanced fluorescence. Also useful for screening of inhibitors for BACE1 & BACE2. Excitation max: ~320 nm; emission max: ~420 nm.
FormLyophilized yellow solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₂H₅₈N₁₂O₁₆
Peptide SequenceAbz-Val-Asn-Leu~Asp-Ala-Glu-EDDnp
Abz = 2-Aminobenzoyl; EDDnp = N-(2,4-dinitrophenyl)ethylenediamine
Purity≥98% by HPLC
SolubilityDMSO (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAndrau, D., et al. 2003. J. Biol. Chem. 278, 25859.