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565770 γ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem

565770
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Tabulka spec. kláve

CAS #Empirical Formula
208255-80-5C₂₃H₂₆F₂N₂O₄

Products

Katalogové čísloBalení ks/bal.
565770-10MG Plastová ampulka 10 mg
565770-5MG Skleněná láhev 5 mg
Description
OverviewA cell-permeable dipeptide that suppresses Aβ production by blocking γ-secretase (Aβtotal IC50 = 115 nM, Aβ42 IC50 = 200 nM). Prevents Aβ34 generation in murine N2a cells and hAPP/hBACE-1 transfected human HEK 293 cells. Reported to be functionally active in both HEK 293 cells and neuronal cultures without affecting the secretion of amyloid-β precursor protein (APP). Also shown to lower Aβ levels acutely in APP-transgenic mice. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice. A 25 mM (5 mg/462 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565784) in DMSO is also available.
Catalogue Number565770
Brand Family Calbiochem®
SynonymsDAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
References
ReferencesMorohashi, Y., et al. 2006. J. Bio. Chem. Vol. 281, 14670.
Nishitomo, K. et al. 2006 J. Neurochem. 99, 1555.
Oddo, S., et al. 2004. Neuron 43, 321.
Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
Sastre, M., et al. 2001. EMBO Rep. 2, 835.
Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
Product Information
CAS number208255-80-5
ATP CompetitiveN
FormLyophilized
Hill FormulaC₂₃H₂₆F₂N₂O₄
Chemical formulaC₂₃H₂₆F₂N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targettotal
Primary Target IC<sub>50</sub>115 nM suppressing Aβtotal production; 200 nM suppressing Aβ42 production
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
565770-10MG 04055977267778
565770-5MG 07790788059941