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428025 α-Latrotoxin, Latrodectus tredecimguttatus - CAS 65988-34-3 - Calbiochem

Causes massive release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates via Ca2+-dependent and -independent parallel mechanisms at concentrations as low as 100 pM.

α-Latrotoxin, Latrodectus tredecimguttatus - CAS 65988-34-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Ltx

428025
  
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Tabulka spec. kláve

CAS #
65988-34-3
Description
OverviewCauses massive release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates via Ca2+-dependent and -independent parallel mechanisms at concentrations as low as 100 pM. Stimulates Ca2+-independent GABA and glutamate release from cortical astrocytes in culture.
Catalogue Number428025
Brand Family Calbiochem®
Synonymsα-Ltx
References
ReferencesParpura, V., et al. 1995. FEBS Lett. 360, 266.
Storchak, L.G., et al. 1994. FEBS Lett. 351, 267.
Osipenko, O.N., et al. 1993. Toxicon 31, 1123.
Valtorta, F., et al. 1988. J. Cell Biol. 107, 2717.
Grasso, A. 1976. Biochem. Biophys. Acta 439, 406.
Frontali, B., et al. 1976. J. Cell Biol. 68, 462.
Product Information
CAS number65988-34-3
ATP CompetitiveN
FormWhite lyophilized solid
ReversibleN
Applications
Biological Information
Biological activityEffective concentration: 100 pm-1 nm
Primary TargetCauses release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates
PurityOne distinct band by SDS-PAGE
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSOE9020000
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
428025 0

Documentation

α-Latrotoxin, Latrodectus tredecimguttatus - CAS 65988-34-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

α-Latrotoxin, Latrodectus tredecimguttatus - CAS 65988-34-3 - Calbiochem Certificates of Analysis

TitleLot Number
428025

References

Přehled odkazů
Parpura, V., et al. 1995. FEBS Lett. 360, 266.
Storchak, L.G., et al. 1994. FEBS Lett. 351, 267.
Osipenko, O.N., et al. 1993. Toxicon 31, 1123.
Valtorta, F., et al. 1988. J. Cell Biol. 107, 2717.
Grasso, A. 1976. Biochem. Biophys. Acta 439, 406.
Frontali, B., et al. 1976. J. Cell Biol. 68, 462.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonymsα-Ltx
DescriptionCauses massive release of exocytotic neurotransmitter synaptic vesicles from a wide variety of central and peripheral synaptic junctions of vertebrates via Ca2+-dependent and independent parallel mechanisms at concentrations as low as 100 pM. Stimulates Ca2+-independent GABA and glutamate release from cortical astrocytes in culture.
FormWhite lyophilized solid
CAS number65988-34-3
RTECSOE9020000
PurityOne distinct band by SDS-PAGE
Biological activityEffective concentration: 100 pm-1 nm
SolubilityDissolve in 0.5 ml cold H₂O with gentle stirring; add 0.5 ml glycerol yeilding a stock solution of 300 nm α-latrotoxin in 50% glycerol.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 year at -20°C.
Toxicity Harmful
ReferencesParpura, V., et al. 1995. FEBS Lett. 360, 266.
Storchak, L.G., et al. 1994. FEBS Lett. 351, 267.
Osipenko, O.N., et al. 1993. Toxicon 31, 1123.
Valtorta, F., et al. 1988. J. Cell Biol. 107, 2717.
Grasso, A. 1976. Biochem. Biophys. Acta 439, 406.
Frontali, B., et al. 1976. J. Cell Biol. 68, 462.