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530654 c-Rel Inhibitor, IT-603 - CAS 292168-90-2 - Calbiochem

A cell-permeable compound that directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity (IC₅₀ = 3 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (5Z)-5-((5-Bromo-2-hydroxy-3-methoxyphenyl)methylidene)-2-sulfanylideneimidazolidin-4-one, (5Z)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxo-4-imidazolidinone, IT603

Primary Target: c-Rel
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530654
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Overview

Key Spec Table

CAS #Empirical Formula
292168-90-2C₁₁H₉BrN₂O₃S

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      		 Glass bottle 10 mg
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      Description
      OverviewA cell-permeable benzylidene-thioxo-imidazolidinone compund that directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity (IC50 = 3 µM in EMSA). Shows good selectivity over Oct1 and AP1. Reduces IL-2 expression in activated T cells without affecting their viability. Induces growth arrest in diffuse large B-cell lymphoma (DLBCL) cell line Ly3 (IC50 = 18 uM). Shown to reduce alloactivation in T cells and diminish graft-versus-host disease (GVHD), but does not impair TCR-mediated killing. Improves the survival rate of lethally irradiated BABL/c mice transplanted with T cell depleted bone marrow cells from C57BL/6 mice (~24 mg/kg, i.p, daily).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530654
      Brand Family Calbiochem®
      Synonyms(5Z)-5-((5-Bromo-2-hydroxy-3-methoxyphenyl)methylidene)-2-sulfanylideneimidazolidin-4-one, (5Z)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxo-4-imidazolidinone, IT603
      References
      ReferencesShono, Y., et al. 2014. Cancer Discovery 4, 578.
      Product Information
      CAS number292168-90-2
      FormDark yellow powder
      Hill FormulaC₁₁H₉BrN₂O₃S
      Chemical formulaC₁₁H₉BrN₂O₃S
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary Targetc-Rel
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.30654.0001CN 04055977260410