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677175 Vinblastine Sulfate - CAS 143-67-9 - Calbiochem

Antitumor alkaloid drug.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2
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677175
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
143-67-9C₄₆H₅₈N₄O₉ · H₂SO₄

Pricing & Availability

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677175-10MGCN
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      		 Plastic ampoule 10 mg
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      Description
      OverviewAntitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases frequency of micronucleated erythrocytes.
      Catalogue Number677175
      Brand Family Calbiochem®
      References
      ReferencesTanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
      Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
      Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
      Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
      Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
      Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
      Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
      Prasad, V., et al. 1992. J. Protein Chem. 11, 509.
      Product Information
      CAS number143-67-9
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₄₆H₅₈N₄O₉ · H₂SO₄
      Chemical formulaC₄₆H₅₈N₄O₉ · H₂SO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInteraction of tubulin with microtubule-associated proteins, specifically Tau and MAP2
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYY8400000
      Safety Information
      R PhraseR: 22-37/38-61-41

      Harmful if swallowed.
      Irritating to respiratory system and skin.
      May cause harm to the unborn child.
      Risk of serious damage to eyes.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      677175-10MGCN 04055977260595

      Documentation

      Vinblastine Sulfate - CAS 143-67-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Vinblastine Sulfate - CAS 143-67-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      677175

      References

      Reference overview
      Tanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
      Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
      Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
      Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
      Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
      Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
      Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
      Prasad, V., et al. 1992. J. Protein Chem. 11, 509.

      Brochure

      Title
      Tools and Tips for Analyzing Apoptosis
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-July-2014 JSW
      DescriptionAntitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases the frequency of micronucleated erythrocytes.
      FormWhite crystalline solid
      CAS number143-67-9
      RTECSYY8400000
      Chemical formulaC₄₆H₅₈N₄O₉ · H₂SO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from moisture
      Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 9982
      ReferencesTanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
      Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
      Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
      Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
      Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
      Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
      Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
      Prasad, V., et al. 1992. J. Protein Chem. 11, 509.