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108219 Tris(hydroxymethyl)aminomethane hydrochloride

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Trometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer

CAS #: 1185-53-1 EC Number: 214-684-5 Molar Mass: 157.60 g/mol Chemical Formula: C₄H₁₁NO₃*ClH Hill Formula: C₄H₁₁NO₃˙ ClH
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108219
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Overview

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Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

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                  Description
                  Catalogue Number108219
                  SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
                  DescriptionTris(hydroxymethyl)aminomethane hydrochloride
                  References
                  Product Information
                  CAS number1185-53-1
                  EC number214-684-5
                  Hill FormulaC₄H₁₁NO₃˙ ClH
                  Chemical formulaC₄H₁₁NO₃*ClH
                  Molar Mass157.60 g/mol
                  HS Code2922 19 99
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ500
                  Applications
                  Biological Information
                  Physicochemical Information
                  Density1.28 g/cm3 (20.2 °C)
                  Melting Point150.7 °C
                  pH value4.2 (100 g/l, H₂O, 20 °C)
                  Vapor pressure<0.1 hPa (50 °C)
                  Solubility561 g/l soluble
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 1 slightly hazardous to water
                  Disposal3
                  Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
                  Safety Information
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStore at +15°C to +25°C.
                  Packaging Information
                  Transport Information
                  Supplemental Information
                  Specifications
                  Appearancewhite to almost white, crystalline powder
                  Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
                  Identity (IR-spectrum)conforms
                  pH-value (0.5 mol/l, water)3.5 - 5.0
                  Melting point147 - 153 °C
                  UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
                  UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
                  UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
                  UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
                  UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
                  Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
                  Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
                  Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
                  Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
                  Other residual solvents (ICH Q3C)excluded by manufacturing process
                  Sulfated ash≤ 0.03
                  Loss on Drying (105°C)≤ 0.5
                  Endotoxins< 2.5
                  Total aerobic microbial count≤ 10²
                  Total yeast and mould count
                  ≤ 10²
                  Salmonella spp.
                  absent in 10 g
                  E.coli
                  absent in 1 g
                  Staphylococcus aureus
                  absent in 1 g
                  Pseudomonas aeruginosa
                  absent in 1 g
                  Candida albicans
                  absent in 1 g
                  Bile tolerante gram negative bacteria
                  absent in 1 g
                  DNases (Exo- and endonucleases)
                  not detected
                  Proteases
                  not detected
                  RNases
                  not detected
                  Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                  Total yeast and mould count
                  ≤ 10²
                  Salmonella spp.
                  absent in 10 g
                  E.coli
                  absent in 1 g
                  Staphylococcus aureus
                  absent in 1 g
                  Pseudomonas aeruginosa
                  absent in 1 g
                  Candida albicans
                  absent in 1 g
                  Bile tolerante gram negative bacteria
                  absent in 1 g
                  DNases (Exo- and endonucleases)
                  not detected
                  Proteases
                  not detected
                  RNases
                  not detected
                  Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                  Global Trade Item Number
                  Catalogue Number GTIN
                  1.08219.1000 04022536101811
                  1.08219.9010 04022536702742
                  1.08219.9012 04027269285586
                  1.08219.9999 04027269043568

                  Documentation

                  Material Qualification Dossier

                  TitleVersion
                  6.0

                  Quality Management Dossier (Open Access)

                  Title

                  Operational Excellence Dossier

                  Title

                  Tris(hydroxymethyl)aminomethane hydrochloride SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

                  Product Number PackagingSpecificationLot Number
                  1.08219.1000 Plastic bottlePDF Specification Document
                  1.08219.9010 Plastic drumPDF Specification Document
                  1.08219.9012 Bucket, plasticPDF Specification Document
                  1.08219.9999 PDF Specification Document

                  Certificates

                  Title