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565850
Sigma-AldrichShikonin - CAS 517-89-5 - Calbiochem
A naphthoquinone found in the Chinese herb Shiunko.
More>>A naphthoquinone found in the Chinese herb Shiunko. Less<<
Shikonin - CAS 517-89-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line.
Catalogue Number
565850
Brand Family
Calbiochem®
Synonyms
Pyruvate Kinase Inhibitor II
References
References
Chen, J., et al. 2011. Oncogene 30, 4297. Li, H., et al. 1999. Phytother. Res.13, 236. Yoon, Y., et al. 1999. Planta Med.65, 532. Hisa, T., et al. 1998. Anticancer Res. 18, 783.
Shikonin - CAS 517-89-5 - Calbiochem Certificates of Analysis
Title
Lot Number
565850
References
Reference overview
Chen, J., et al. 2011. Oncogene 30, 4297. Li, H., et al. 1999. Phytother. Res.13, 236. Yoon, Y., et al. 1999. Planta Med.65, 532. Hisa, T., et al. 1998. Anticancer Res. 18, 783.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
17-December-2018 JSW
Synonyms
Pyruvate Kinase Inhibitor II
Description
A naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC50 <1 µM) over PKM1 and PKL activities (IC50 in the range of 10-20 µM), and inhibits cancer cell glycolysis.
Form
Red solid
CAS number
517-89-5
RTECS
QL8000200
Chemical formula
C₁₆H₁₆O₅
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (10 mg/ml)
Storage
Protect from light -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Chen, J., et al. 2011. Oncogene 30, 4297. Li, H., et al. 1999. Phytother. Res.13, 236. Yoon, Y., et al. 1999. Planta Med.65, 532. Hisa, T., et al. 1998. Anticancer Res. 18, 783.
