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573102 STAT3 Inhibitor VI, S3I-201 - CAS 501919-59-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
501919-59-1C₁₆H₁₅NO₇S

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573102-10MGCN
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      Description
      OverviewA cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). Also available as a 50 mM solution in DMSO (Cat. No. 573130).
      Catalogue Number573102
      Brand Family Calbiochem®
      Synonyms2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid, NSC 74859
      References
      ReferencesLin, L., et al. 2009. Oncogene, 28, 961.
      Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.
      Product Information
      CAS number501919-59-1
      FormLight beige solid
      Hill FormulaC₁₆H₁₅NO₇S
      Chemical formulaC₁₆H₁₅NO₇S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      573102-10MGCN 04055977266429