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557368
Sigma-AldrichRotenone - CAS 83-79-4 - Calbiochem
A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain.
More>>A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Less<<
Rotenone - CAS 83-79-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.
Catalogue Number
557368
Brand Family
Calbiochem®
References
References
Kopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol.428, 311. Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807. Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.
Toxic if swallowed. Irritating to eyes, respiratory system and skin. Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
S Phrase
S: 22-24/25-36-45-60-61
Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). This material and its container must be disposed of as hazardous waste. Avoid release to the environment. Refer to special instructions/safety data sheet.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C.
Rotenone - CAS 83-79-4 - Calbiochem Certificates of Analysis
Title
Lot Number
557368
References
Reference overview
Kopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol.428, 311. Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807. Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
17-October-2019 JSW
Description
A mitochondrial toxin and a potent, reversible and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.
Form
White to off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
83-79-4
RTECS
DJ2800000
Chemical formula
C₂₃H₂₂O₆
Structure formula
Purity
≥97% by HPLC
Solubility
Chloroform (50 mg/ml), DMSO (50 mg/ml), or ethanol (5 mg/ml)
Storage
Protect from light +15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C.
Toxicity
Toxic
Merck USA index
14 8271
References
Kopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol.428, 311. Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807. Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.
