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540220 Purmorphamine - CAS 483367-10-8 - Calbiochem

A cell-permeable activator of Hedgehog signaling that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC₅₀ = 1 µM).

Purmorphamine - CAS 483367-10-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist

Primary Target: Activation of the Hedgehog signaling pathway
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540220
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Overview

Key Spec Table

CAS #Empirical Formula
483367-10-8C₃₁H₃₂N₆O₂

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      Description
      OverviewA cell-permeable 2,6,9-trisubstituted purine compound that induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 (EC50 = 1 µM) and lineage-committed preosteoblasts MC3T3-E1. Its effect can be synergized with that of BMP-4 (bone morphogenetic protein-4) and has been shown to induce transdifferentiation even in preadipocytes and myoblasts. Reported to induce osteogenesis by activation of the Hedgehog signaling pathway. A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540223) in DMSO is also available.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number540220
      Brand Family Calbiochem®
      Synonyms2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine, Shh Signaling Agonist
      References
      ReferencesWu, X., et al. 2004. Chem. Biol. 11, 1229.
      Wu, X., et al. 2002. J. Am. Chem. Soc. 124, 14520.
      Product Information
      CAS number483367-10-8
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₃₁H₃₂N₆O₂
      Chemical formulaC₃₁H₃₂N₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetActivation of the Hedgehog signaling pathway
      Primary Target IC<sub>50</sub>EC50 = 1 µM for inducing osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 22-68

      Harmful if swallowed.
      Possible risks of irreversible effects.
      S PhraseS: 22-36/37

      Do not breathe dust.
      Wear suitable protective clothing and gloves.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      540220-5MGCN 07790788051389