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481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII

Primary Target: translocation of the NF-κB active complex into the nucleus
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481480
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Overview

Key Spec Table

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

Pricing & Availability

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481480-500UGCN
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      		 Plastic ampoule 500 μg
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      Description
      OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
      Catalogue Number481480
      Brand Family Calbiochem®
      SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
      References
      ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
      Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
      Hygroscopic Hygroscopic
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Biological Information
      Primary Targettranslocation of the NF-κB active complex into the nucleus
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide ContentY
      Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Global Trade Item Number
      Catalogue Number GTIN
      481480-500UGCN 04055977183788