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509884 Myristoylated-FEEERA, mP6 - Calbiochem

A cell-permeable myristoylated hexapeptide that selectively inhibits integrin outside-in signaling without affecting inside-out signaling. Blocks the interaction of Gα3 and integrin β3 subunit.

Myristoylated-FEEERA, mP6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Integrin Signaling Inhibitor I, mP6

Primary Target: platelet integrin →IIb→3
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509884
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₇H₇₅N₉O₁₄

Pricing & Availability

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      Description
      OverviewA cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509884
      Brand Family Calbiochem®
      SynonymsIntegrin Signaling Inhibitor I, mP6
      References
      ReferencesShen, B., et al. 2013. Nature 503, 131.
      Product Information
      FormWhite powder
      Hill FormulaC₄₇H₇₅N₉O₁₄
      Chemical formulaC₄₇H₇₅N₉O₁₄
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetplatelet integrin →IIb→3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceFEEERA
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.09884.0001CN 04055977241136

      Documentation

      Myristoylated-FEEERA, mP6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Shen, B., et al. 2013. Nature 503, 131.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-May-2014 JSW
      SynonymsIntegrin Signaling Inhibitor I, mP6
      DescriptionA cell-permeable myristoylated hexapeptide derived from EXE-motif-containing integrin β3 subunit that selectively inhibits integrin outside-in signaling without affecting inside-out signaling . Shown to specifically block the interaction of Gα3 and integrin β3 subunit resulting in the inhibition of Gα13-dependent early phase outside-in signaling. Selectively inhibits thrombosis without affecting haemostasis.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₇H₇₅N₉O₁₄
      Peptide SequenceFEEERA
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-207deg;C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShen, B., et al. 2013. Nature 503, 131.