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FCMAB217F Milli-Mark™ Anti-CD235a-FITC Antibody, clone JC159

Detect CD235a using this Milli-Mark Anti-CD235a-FITC Antibody, clone JC159 validated for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P02724
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FCMAB217F
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB217F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-CD235a-FITC Antibody, clone JC159
      Alternate Names
      • Glycophorin-A
      • PAS-2
      • Sialoglycoprotein alpha
      • MN sialoglycoprotein
      Background InformationGlycophorin A, CD235a, is a single-pass membrane sialoglycoprotein and carrier of the blood group specificities M and N. The gene is located on chromosome 4q28-q31 and share sequence homology with genes encoding glycophorin B and glycophorin E (van der Schoot, 2002). Glycophorin A is expressed by erythroid cells beginning on morphologically recognizable erythroid precursors, just after the CFU-E stage, to the mature erythrocyte. Once glycophorin A is maximally expressed, the amount in each erythroid cell remains constant and does not appear to change during further maturation (Loken, 1987).
      References
      Product Information
      FormatFITC
      Control
      • Human Lymphocytes
      PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
      Quality LevelMQ100
      Applications
      ApplicationDetect CD235a using this Milli-Mark Anti-CD235a-FITC Antibody, clone JC159 validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenMembrane extracts of hairy cell leukemia prepared from human spleen
      CloneJC159
      HostMouse
      SpecificityAntibody recognizes Human CD235a antigen.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGlycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryGlycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
      Molecular Weight 16 kDa (calculated)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using human lymphocytes
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB217F 04053252375514

      Documentation

      Milli-Mark™ Anti-CD235a-FITC Antibody, clone JC159 SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark™ Anti-CD235a-FITC Antibody, clone JC159 Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-CD235a-FITC, clone JC159 - 2002195 2002195
      Milli-Mark Anti-CD235a-FITC, clone JC159 - 2048219 2048219
      Milli-Mark Anti-CD235a-FITC, clone JC159 - NRG1775606 NRG1775606
      Milli-Mark™ Anti-CD235a-FITC, -2574722 2574722
      Milli-Mark™ Anti-CD235a-FITC, -2716645 2716645
      Milli-Mark™ Anti-CD235a-FITC, -2780436 2780436
      Milli-Mark™ Anti-CD235a-FITC, clone JC159 - 3427189 3427189
      Milli-Mark™ Anti-CD235a-FITC, clone JC159 - 3832721 3832721
      Milli-Mark™ Anti-CD235a-FITC, clone JC159 - 3905331 3905331
      Milli-Mark™ Anti-CD235a-FITC, clone JC159 - 4188778 4188778
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