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428020 Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem

Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Actin polymerization
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428020
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
76343-94-7C₂₀H₂₉NO₅S

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      		 Plastic ampoule 1 mg
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      Description
      OverviewA structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes; 10 to 100-fold more potent than cytochalasins.
      Catalogue Number428020
      Brand Family Calbiochem®
      References
      ReferencesSpector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      de Oliveira, C.A., and Mantovani, B. 1988. Life Sci. 43, 1825.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Spector, I., et al. 1983. Science 219, 493.
      Product Information
      CAS number76343-94-7
      ATP CompetitiveN
      FormOff-white to yellow solid
      Hill FormulaC₂₀H₂₉NO₅S
      Chemical formulaC₂₀H₂₉NO₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetActin polymerization
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      428020-1MGCN 04055977210453

      Documentation

      Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      428020

      References

      Reference overview
      Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      de Oliveira, C.A., and Mantovani, B. 1988. Life Sci. 43, 1825.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Spector, I., et al. 1983. Science 219, 493.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-January-2011 JSW
      DescriptionA structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.
      FormOff-white to yellow solid
      CAS number76343-94-7
      Chemical formulaC₂₀H₂₉NO₅S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml), Methanol (50 mg/ml),or Ethanol (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 5378
      ReferencesSpector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      de Oliveira, C.A., and Mantovani, B. 1988. Life Sci. 43, 1825.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Spector, I., et al. 1983. Science 219, 493.