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420600
Sigma-AldrichKetoconazole - CAS 65277-42-1 - Calbiochem
An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities.
More>>An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Less<<
Ketoconazole - CAS 65277-42-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
Catalogue Number
420600
Brand Family
Calbiochem®
Synonyms
cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
References
References
van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231. Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883. Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999. Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882. Lelcuk, S., et al. 1984. J. Trauma 24, 393.
Toxic if swallowed. Limited evidence of a carcinogenic effect. Possible risk of harm to the unborn child. Irritating to eyes, respiratory system and skin.
S Phrase
S: 22-26-36
Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Ketoconazole - CAS 65277-42-1 - Calbiochem Certificates of Analysis
Title
Lot Number
420600
References
Reference overview
van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231. Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883. Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999. Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882. Lelcuk, S., et al. 1984. J. Trauma 24, 393.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
13-May-2008 RFH
Synonyms
cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
Description
An inhibitor of cytochrome P-450 in steroid biosynthesis. An anti-fungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
Form
Off-white solid
CAS number
65277-42-1
RTECS
TK7912300
Chemical formula
C₂₆H₂₈Cl₂N₄O₄
Structure formula
Purity
≥98% by HPLC
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Toxicity
Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 5302
References
van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231. Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883. Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999. Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882. Lelcuk, S., et al. 1984. J. Trauma 24, 393.
