Millipore Sigma Vibrant Logo

420298 K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

K-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CaM kinase II
View Products on Sigmaaldrich.com
420298
View Pricing & Availability

Overview

Key Spec Table

CAS #Empirical Formula
97161-97-2C₂₇H₂₁N₃O₅

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
420298-100UGCN
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 100 μg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Add To Favorites
      Description
      OverviewA cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
      Catalogue Number420298
      Brand Family Calbiochem®
      References
      ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
      Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
      Tapley, P., et al. 1992. Oncogene 7, 371.
      Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
      Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
      Product Information
      CAS number97161-97-2
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₂₇H₂₁N₃O₅
      Chemical formulaC₂₇H₂₁N₃O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationK-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk).
      Biological Information
      Primary TargetCaM kinase II
      Primary Target K<sub>i</sub>1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSNZ0550000
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      420298-100UGCN 04055977210910