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407950 Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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407950
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
56092-81-0C₄₁H₇₂O₉

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407950-10MGCN
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      407950-1MGCN
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          407950-5MGCN
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              Description
              OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
              Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
              Catalogue Number407950
              Brand Family Calbiochem®
              References
              ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
              Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
              Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
              Lee, H.C. 1993. J. Biol. Chem. 268, 293.
              Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
              Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
              Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
              Product Information
              CAS number56092-81-0
              ATP CompetitiveN
              FormWaxy solid
              Hill FormulaC₄₁H₇₂O₉
              Chemical formulaC₄₁H₇₂O₉
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
              Biological Information
              Primary TargetMobile ion carrier for Ca2+
              Purity≥90% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSNO0600000
              Safety Information
              R PhraseR: 22

              Harmful if swallowed.
              S PhraseS: 36

              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              407950-10MGCN 04055977211566
              407950-1MGCN 04055977211559
              407950-5MGCN 04055977211573

              Documentation

              Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem Certificates of Analysis

              TitleLot Number
              407950

              References

              Reference overview
              Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
              Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
              Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
              Lee, H.C. 1993. J. Biol. Chem. 268, 293.
              Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
              Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
              Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

              Brochure

              Title
              Caspases and other Apoptosis Related Tools Brochure

              Citations

              Title
            • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
              		•
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision16-April-2010 JSW
              DescriptionHighly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
              FormWaxy solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number56092-81-0
              RTECSNO0600000
              Chemical formulaC₄₁H₇₂O₉
              Structure formulaStructure formula
              Purity≥90% by HPLC
              SolubilityDMSO (10 mg/ml) and Methanol (10 mg/ml)
              Storage Protect from light
              +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
              Toxicity Harmful
              ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
              Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
              Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
              Lee, H.C. 1993. J. Biol. Chem. 268, 293.
              Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
              Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
              Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
              Citation
            • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
              		•

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores