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407241 Insulin Degrading Enzyme, His•Tag®, Rat, Recombinant, S. frugiperda

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Insulysin, IDE

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407241
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Overview

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407241-50UGCN
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      Description
      OverviewRecombinant, rat insulin degrading enzyme fused to a His•Tag® sequence and expressed in S. frugiperda insect cells. A metalloprotease that degrades insulin and a variety of other peptides including amyloid peptides.
      Catalogue Number407241
      Brand Family Calbiochem®
      SynonymsInsulysin, IDE
      References
      ReferencesHersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
      Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
      Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
      Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
      Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
      Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.
      EC number3.4.24.56
      FormLiquid
      FormulationIn 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥3 U/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407241-50UGCN 04055977188646

      Documentation

      Insulin Degrading Enzyme, His•Tag®, Rat, Recombinant, S. frugiperda SDS

      Title

      Safety Data Sheet (SDS) 

      Insulin Degrading Enzyme, His•Tag®, Rat, Recombinant, S. frugiperda Certificates of Analysis

      TitleLot Number
      407241

      References

      Reference overview
      Hersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
      Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
      Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
      Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
      Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
      Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-March-2008 JSW
      SynonymsInsulysin, IDE
      DescriptionRecombinant, rat insulin degrading enzyme fused to a His•Tag® sequence and expressed in S. frugiperda insect cells. Insulin degrading enzyme (Insulysin) is a metalloprotease that degrades insulin and a variety of other peptides, including glucagon, insulin-like growth factors I and II, atrial natriuretic peptide, TGF-α, and amyloid peptides. Reported to be inversely correlated with brain Aβ peptide levels in insulysin-deficient mice compared to wild-type mice.
      FormLiquid
      FormulationIn 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.
      Concentration Label Please refer to vial label for lot-specific concentration
      EC number3.4.24.56
      Purity≥90% by SDS-PAGE
      Specific activity≥3 U/mg protein
      Unit definitionOne unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesHersh, L.B. 2003. Curr. Pharm. Des. 9, 449.
      Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6221.
      Song, E.S., et al. 2003. J. Biol. Chem. 278, 49789.
      Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimers Dis. 4, 341.
      Song, E.S., et al. 2001. J. Biol. Chem. 276, 1152.
      Becker, A.B., and Roth, R.A. 1995. Methods Enzymol. 248, 693.