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509228 InSolution™ Y-27632, Sterile-Filtered, Cell Culture-Tested - CAS 146986-50-7 - Calbiochem

InSolution™ Y-27632, Sterile-Filtered, Cell Culture-Tested, CAS 146986-50-7, is a 10 mM sterile-filtered solution of Y-27632 in H₂O. Acts as an inhibitor of Rho kinases (Ki = 140 nM for p160ROCK).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: ROCK
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509228
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
146986-50-7C₁₄H₂₁N₃O · 2HCl

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      Description
      Catalogue Number509228
      Brand Family Calbiochem®
      References
      ReferencesLi X. et al, et. Al., 2009. Human Reproduction, 24, 580.
      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
      Hirose, M., et al. 1999. J. Cell Biol. 141, 1625.
      Maekawa, M., et al. 1999. Science. 285, 895.
      Uehata, M., et al. 1997. Nature. 389, 990.
      Product Information
      CAS number146986-50-7
      FormLiquid
      FormulationA 10 mM (2 mg/591 µL) sterile-filtered solution of Y-27632 (Cat. No. 688000) in H₂O.
      Hill FormulaC₁₄H₂₁N₃O · 2HCl
      Chemical formulaC₁₄H₂₁N₃O · 2HCl
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ Y-27632, Sterile-Filtered, Cell Culture-Tested, CAS 146986-50-7, is a 10 mM sterile-filtered solution of Y-27632 in H₂O. Acts as an inhibitor of Rho kinases (Ki = 140 nM for p160ROCK).
      Biological Information
      Primary TargetROCK
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.09228.0001CN 04055977241716

      Documentation

      InSolution™ Y-27632, Sterile-Filtered, Cell Culture-Tested - CAS 146986-50-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Li X. et al, et. Al., 2009. Human Reproduction, 24, 580.
      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
      Hirose, M., et al. 1999. J. Cell Biol. 141, 1625.
      Maekawa, M., et al. 1999. Science. 285, 895.
      Uehata, M., et al. 1997. Nature. 389, 990.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-April-2014 JSW
      DescriptionReady to use, cell culture-tested, suitable for stem cell applications. Acts as a highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also shown to improve survival of human stem cells especially during cell culture passage and manipulation.
      FormLiquid
      FormulationA 10 mM (2 mg/591 µL) sterile-filtered solution of Y-27632 (Cat. No. 688000) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number146986-50-7
      Chemical formulaC₁₄H₂₁N₃O · 2HCl
      Purity≥95% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLi X. et al, et. Al., 2009. Human Reproduction, 24, 580.
      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
      Hirose, M., et al. 1999. J. Cell Biol. 141, 1625.
      Maekawa, M., et al. 1999. Science. 285, 895.
      Uehata, M., et al. 1997. Nature. 389, 990.