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400087 HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem

The HIF-2α Translation Inhibitor, also referenced under CAS 882268-69-1, controls the biological activity of HIF-2α. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Hypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II

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400087
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
882268-69-1C₉H₉N₃O₄S₂

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      Description
      OverviewA cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
      Catalogue Number400087
      Brand Family Calbiochem®
      SynonymsHypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
      References
      ReferencesZimmer, M., et al. 2008. Mol. Cell 32, 838.
      Product Information
      CAS number882268-69-1
      FormAmber solid
      Hill FormulaC₉H₉N₃O₄S₂
      Chemical formulaC₉H₉N₃O₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥95% (sum of two isomers)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      400087-10MGCN 04055977212341

      Documentation

      HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      HIF-2α Translation Inhibitor - CAS 882268-69-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      400087

      References

      Reference overview
      Zimmer, M., et al. 2008. Mol. Cell 32, 838.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsHypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
      DescriptionA cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5-10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
      FormAmber solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number882268-69-1
      Chemical formulaC₉H₉N₃O₄S₂
      Structure formulaStructure formula
      Purity≥95% (sum of two isomers)
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesZimmer, M., et al. 2008. Mol. Cell 32, 838.