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368059 Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem

A fluorogenic substrate for the detection of granzyme B and caspase-8 activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-IETD-AFC, Caspase-8 Substrate II

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368059
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Overview

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      368059-5MGCN
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          Description
          OverviewA fluorogenic substrate for the detection of granzyme B and caspase-8 activity. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
          Catalogue Number368059
          Brand Family Calbiochem®
          SynonymsZ-IETD-AFC, Caspase-8 Substrate II
          References
          ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
          Product Information
          CAS number219138-02-0
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₃₇H₄₂F₃N₅O₁₃
          Chemical formulaC₃₇H₄₂F₃N₅O₁₃
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetFluorogenic substrate for the detection of granzyme B and caspase-8 activity
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Emission max.
          Excitation max.
          Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          368059-1MGCN 07790788049621
          368059-5MGCN 04055977192179

          Documentation

          Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          368059

          References

          Reference overview
          Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-July-2008 RFH
          SynonymsZ-IETD-AFC, Caspase-8 Substrate II
          DescriptionA fluorogenic substrate for the detection of granzyme B. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
          FormWhite lyophilized solid
          CAS number219138-02-0
          Chemical formulaC₃₇H₄₂F₃N₅O₁₃
          Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
          Purity≥97% by HPLC
          SolubilityDMSO (1 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.

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          Categories

          Life Science Research > Inhibitors and Biochemicals