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341608 FGF Receptor Tyrosine Kinase Inhibitor - CAS 192705-79-6 - Calbiochem

The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for

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Synonyms: 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD 166866

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341608
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Overview

Key Spec Table

CAS #Empirical Formula
192705-79-6C₂₀H₂₄N₆O₃

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341608-5MGCN
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      Description
      OverviewA cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC50 = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC50 > 50 µM).
      Catalogue Number341608
      Brand Family Calbiochem®
      Synonyms1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD 166866
      References
      ReferencesPanek, R.L., et al. 1998. J. Pharm. Exp. Ther. 286, 569.
      Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296.
      Product Information
      CAS number192705-79-6
      FormOff-white solid
      Hill FormulaC₂₀H₂₄N₆O₃
      Chemical formulaC₂₀H₂₄N₆O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      341608-5MGCN 04055977195217