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300260 Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
4673-26-1C₁₂H₈ICl

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300260-10MGCN
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      Description
      OverviewA cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Also inhibits iNOS in macrophages (IC50 = 50 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADPH-ubiquinone oxido-reductase.
      Catalogue Number300260
      Brand Family Calbiochem®
      SynonymsDPI
      References
      ReferencesWang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
      Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
      Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
      Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
      Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
      Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
      Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.
      Product Information
      CAS number4673-26-1
      ATP CompetitiveN
      FormOff-white crystalline solid
      Hill FormulaC₁₂H₈ICl
      Chemical formulaC₁₂H₈ICl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargeteNOS
      Primary Target IC<sub>50</sub>180 nM against endothelial nitric oxide synthase (eNOS)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 42/43-63

      May cause sensitization by inhalation and skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      300260-10MGCN 04055977197976