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309795 DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem

Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na

Primary Target: Cl- uptake
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309795
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
53005-05-3C₁₆H₈N₂O₆S₄ · 2Na

Pricing & Availability

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309795-250MGCN
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      		 Plastic ampoule 250 mg
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      Description
      OverviewBinds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl– uptake (IC50 = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.
      Catalogue Number309795
      Brand Family Calbiochem®
      Synonyms4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
      References
      ReferencesBettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
      Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
      Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
      Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.
      Product Information
      CAS number53005-05-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₆H₈N₂O₆S₄ · 2Na
      Chemical formulaC₁₆H₈N₂O₆S₄ · 2Na
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCl- uptake
      Primary Target IC<sub>50</sub>150 nM inhibiting Cl- uptake in neuroblastoma cells
      Purity≥85% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      309795-250MGCN 04055977216790

      Documentation

      DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      DIDS, Disodium Salt - CAS 53005-05-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      309795

      References

      Reference overview
      Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
      Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
      Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
      Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-February-2024 JSW
      Synonyms4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
      DescriptionBinds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl- uptake (IC50 = 150 nM) in neuroblastoma cells. Has antiulcerous activity.
      FormYellow solid
      CAS number53005-05-3
      Chemical formulaC₁₆H₈N₂O₆S₄ · 2Na
      Structure formulaStructure formula
      Purity≥85% by HPLC
      SolubilityH₂O (0.5%)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Irritant
      ReferencesBettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
      Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
      Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
      Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol. 15, 207.