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217505 CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem

The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Luciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor

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217505
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
92-78-4C₁₇H₁₂ClNO₂

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217505-250MGCN
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      Description
      OverviewA cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 µM, respectively) by directly binding to CBP's KIX domain (Kd ~8.6 µM using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC50 <2.5 µM), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 µM), but not that of RLuc.
      Catalogue Number217505
      Brand Family Calbiochem®
      SynonymsLuciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor
      References
      ReferencesLi, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721.
      Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622.
      Product Information
      CAS number92-78-4
      FormBeige solid
      Hill FormulaC₁₇H₁₂ClNO₂
      Chemical formulaC₁₇H₁₂ClNO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      217505-250MGCN 04055977219371

      Documentation

      CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CBP-CREB Interaction Inhibitor - CAS 92-78-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      217505

      References

      Reference overview
      Li, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721.
      Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-August-2010 RFH
      SynonymsLuciferase Inhibitor III, N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide, KIX-KID Interaction Inhibitor
      DescriptionA cell-permeable naphthamide compound that effectively blocks the interaction between the KIX domain of CBP and the KID domain of CREB in HEK293T-based and cell-free Renilla luciferase (RLuc) complementation assays (IC50 = 2.26 and 2.9 µM, respectively) by directly binding to CBP's KIX domain (Kd ~8.6 µM using a recombinant KIX). Shown to inhibit CRE- (cAMP response element) dependent transcription activity induced by forskolin (Cat. No. 344270) in a HEK293T-based RLuc reporter assay (IC50 <2.5 µM), while exhibiting little effect against the KID-independent CREB-VP16 transcription activity. Also reported to inhibit the enzymatic activity of Firefly luciferase (IC50 ~1 µM), but not that of RLuc.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number92-78-4
      Chemical formulaC₁₇H₁₂ClNO₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLi, B.X. and Xiao, X., 2009. ChemBioChem 10, 2721.
      Best, J.L., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 17622.