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505980 Autophagy Inhibitor IV, Cpd18 - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₁₂H₁₇N₅

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K. Shown to block 80% of starvation-induced autophagy at 1 mM (IC50 = 0.67 mM, compared with 3-MA at 6 mM). Displays much better solubility than 3-MA (5 times more soluble in water and 30 times more soluble in DMSO). Also found to reduce cell viability by 55% at 1 mM at 12 hours compared with 72% reduction for 3-MA at 10 mM.

      Please note that the molecular weight for this compound is lot-specific due to variable water content.
      Catalogue Number505980
      Brand Family Calbiochem®
      Synonyms3-methyl-6-(3-methylpiperidin-1-yl)-3H-purine, 3-MA analog, Cpd 18
      References
      ReferencesWu, Y., et al, 2013. Autophagy9, 595.
      Product Information
      FormWhite solid
      Hill FormulaC₁₂H₁₇N₅
      Chemical formulaC₁₂H₁₇N₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetPI3K
      Primary Target IC<sub>50</sub>0.67 mM
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      5.05980.0001CN 04055977262520