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189485 Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable, is a specific, potent inhibitor of CaMKII. Contains the Antennapedia transport peptide fused to the amino terminus of AIP-II.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH, Ant-A3K/V10F-AIP, Ant-AIP-II

Primary Target: cam Kinase-2
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189485
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇₇H₂₉₁N₅₇O₃₉S

Pricing & Availability

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189485-1MGCN
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      		 Plastic ampoule 1 mg
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      Description
      OverviewA highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitor that contains the Antennapedia transport peptide sequence fused to the amino terminus of AIP-II (Cat. No. 189484).
      Catalogue Number189485
      Brand Family Calbiochem®
      SynonymsAc-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH, Ant-A3K/V10F-AIP, Ant-AIP-II
      References
      ReferencesWatterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
      Ishida, A., et al. 1998. FEBS Lett. 427, 115.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₇₇H₂₉₁N₅₇O₃₉S
      Chemical formulaC₁₇₇H₂₉₁N₅₇O₃₉S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ200
      Applications
      ApplicationAutocamtide-2 Related Inhibitory Peptide II, Cell-permeable, is a specific, potent inhibitor of CaMKII. Contains the Antennapedia transport peptide fused to the amino terminus of AIP-II.
      Biological Information
      Primary Targetcam Kinase-2
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      189485-1MGCN 04055977221800

      Documentation

      Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      189485

      References

      Reference overview
      Watterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
      Ishida, A., et al. 1998. FEBS Lett. 427, 115.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      SynonymsAc-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH, Ant-A3K/V10F-AIP, Ant-AIP-II
      DescriptionA highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II) (Cat. No. 189484). AIP-II is an AIP analog where Ala3 and Val10 are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala286) and KN-93 (Cat. No. 422708). Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇₇H₂₉₁N₅₇O₃₉S
      Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml), H₂O (1 mg/ml), or 5% Acetic Acid (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesWatterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
      Ishida, A., et al. 1998. FEBS Lett. 427, 115.