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07-806 Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody

Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody is an antibody against phospho-c-Kit (Tyr568/Tyr570) for use in WB.

Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: KIT, C-Kit, PBT, CD117, SCFR, c-kit UniProt Number: P10721
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07-806
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-806
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-c-Kit (Tyr568/Tyr570) Antibody
      Alternate Names
      • KIT
      • CD117
      • PBT
      • SCFR
      • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
      References
      Product Information
      FormatAffinity Purified
      Quality LevelMQ100
      Applications
      ApplicationAnti-phospho-c-Kit (Tyr568/Tyr570) Antibody is an antibody against phospho-c-Kit (Tyr568/Tyr570) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, cow and dog. phospho-c-Kit (Tyr568/ Tyr570).
      HostRabbit
      SpecificityRecognizes phospho-c-Kit (Tyr568/ Tyr570)
      IsotypeIgG
      Species Reactivity
      • Human
      Species Reactivity NotePredicted to cross-react with Mouse and Rat based on complete sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • KIT
      • C-Kit
      • PBT
      • CD117
      • SCFR
      • c-kit
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
      SIZE: 976 amino acids; 109865 Da
      SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
      SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-806 04053252677540

      Documentation

      Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho-c-Kit (Tyr568/Tyr570) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-c-Kit (Tyr568/Tyr570) - 2152455 2152455
      Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) - 2386933 2386933
      Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) 2969383
      Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) 3093138
      Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) - 2280199 2280199
      Anti-phospho-c-Kit (Tyr568/Tyr570) (Affinity purified Rabbit polyclonal IgG) - DAM1408789 DAM1408789
      Anti-phospho-c-Kit (Tyr568/Tyr570) - 0608038400 0608038400
      Anti-phospho-c-Kit (Tyr568/Tyr570) - 3907841 3907841
      Anti-phospho-c-Kit (Tyr568/Tyr570) - 3949240 3949240
      Anti-phospho-c-Kit (Tyr568/Tyr570) - 4010047 4010047
      Show more

      References

      Reference overviewPub Med ID
      Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes
      Price, D J, et al
      J Biol Chem, 272:5915-20 (1997)  1997

      		9038210 9038210

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies