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MABC519 Anti-Trop2, clone 2G10, Azide Free Antibody

This Anti-Trop2 antibody, clone 2G10, Azide Free is validated for use in ICC, flow cytometry & inhibition for the detection of Trop2.

Anti-Trop2, clone 2G10, Azide Free Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TACSTD2, GA733-1, M1S1, TROP2 UniProt Number: P09758
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MABC519
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, FC, InhibitionMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC519
      DescriptionAnti-Trop2, clone 2G10, Azide Free Antibody
      Alternate Names
      • Tumor-associated calcium signal transducer 2
      • Cell surface glycoprotein Trop-2
      • Membrane component chromosome 1 surface marker 1
      • Pancreatic carcinoma marker protein GA733-1
      Background InformationThe protein known as Trop-2, or also known as cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1 or Pancreatic carcinoma marker protein GA733-1 and encoded by the gene TACSTD2/GA733-1/M1S1/TROP2, is a protein that may function as a growth factor receptor and is expressed primarily in the placenta, lung and epithelial tissues but also found in certain cancers. The protein was first identified as a carcinoma antigen by the monoclonal GA733. It is a plasma membrane bound protein that transduces an intracellular calcium signal after binding unknown ligands. Mutations in Trop2 are associated with a rare eye disease leading to blindness. Trop-2 has also recently been shown to be important in regulating fibroblast motility and lung cell proliferation via the regulation of the ERK kinase pathway as well as several critical components of the cell migration apparatus.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing PBS without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Trop2 antibody, clone 2G10, Azide Free is validated for use in ICC, flow cytometry & inhibition for the detection of Trop2.
      Key Applications
      • Immunocytochemistry
      • Flow Cytometry
      • Inhibition
      Application NotesImmunocytochemistry Analysis: A representative lot detected Trop2 in MTE 4-14/T2 and MCF7 cells (Prof. Saverio Alberti, Oncoxx Biotec.).

      Flow Cytometry Analysis: A representative lot detected Trop2 in transfected cells, Skov-3 cancer cells, and HT29 cancer cells (Prof. Saverio Alberti, Oncoxx Biotec.).

      Inhibition Analysis: A representative lot inhibited tumor growth in DU145 prostate cancer cells, and in HT-29, HCT116 and Colo205 cells. (Note: When used together, Cat. No. MABC519, Anti-Trop2, clone 2G10, Azide Free and Cat. No. MABC518, Anti-Trop2, clone 2EF, Azide Free maximizes inhibition of tumor growth in vivo.) (Prof. Saverio Alberti, Oncoxx Biotec.).
      Biological Information
      ImmunogenRecombinant protein corresponding to the extracellular domain of human Trop2.
      Clone2G10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TACSTD2
      • GA733-1
      • M1S1
      • TROP2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight36 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry Analysis in MET cells transfected with a vector expressing Trop2 or with an empty vector.

      Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected Trop 2 in MET cells transfected with a vector expressing Trop2 and not in MET cells transfected with an empty vector.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC519 04053252955860

      Documentation

      Anti-Trop2, clone 2G10, Azide Free Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Trop2, clone 2G10, Azide Free Antibody Certificates of Analysis

      TitleLot Number
      Anti-Trop2, clone 2G10, Azide Free - Q2385777 Q2385777
      Anti-Trop2, clone 2G10, Azide Free - 3305857 3305857
      Anti-Trop2, clone 2G10, Azide Free - 3534053 3534053
      Anti-Trop2, clone 2G10, Azide Free - 3698003 3698003
      Anti-Trop2, clone 2G10, Azide Free - 3738438 3738438
      Anti-Trop2, clone 2G10, Azide Free - 3915567 3915567
      Anti-Trop2, clone 2G10, Azide Free - 3922569 3922569
      Anti-Trop2, clone 2G10, Azide Free -2815150 2815150