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AB5087 Anti-Melanocyte Stimulating Hormone α Antibody

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AB5087
50 µL  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MaIHC, RIAShSerumPolyclonal Antibody
      Description
      Catalogue NumberAB5087
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Melanocyte Stimulating Hormone α Antibody
      Alternate Names
      • alpha-MSH
      • POMC
      • Pro-opiomelanocortin
      • Corticotropin-lipotropin precursor
      Product Information
      FormatSerum
      Control
      • Hypothalamus
      PresentationSheep Serum. Liquid. Contains no preservative.
      Quality LevelMQ300
      Applications
      ApplicationAnti-Melanocyte Stimulating Hormone Antibody, α detects level of Melanocyte Stimulating Hormone & has been published & validated for use in IH, RIA.
      Key Applications
      • Immunohistochemistry
      • Radioimmunoassay
      Application NotesImmunohistochemistry: 1:10,000-1:50,000 on 4% paraformaldehyde fixed tissue.

      RIA: 1:250,000-1:300,000.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenMSH conjugated with bovine thyroglobulin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostSheep
      SpecificitySpecific for alpha-melanocyte stimulating hormone (aMSH), C-terminal.
      Species Reactivity
      • Mammals
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
      Gene Symbol
      • POMC
      • LPH
      • NPP
      • POC
      • ACTH
      • CLIP
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
      SIZE: 267 amino acids; 29424 Da
      TISSUE SPECIFICITY: Melanocytes and corticoadrenal tissue. Produced by the pituitary gland.
      SIMILARITY: Belongs to the POMC family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size50 µL
      Global Trade Item Number
      Catalogue Number GTIN
      AB5087 04053252736599