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MAB2638 Anti-Integrin beta7 Antibody, clone TN114

Anti-Integrin beta7 Antibody, clone TN114 is an antibody against Integrin beta7 for use in FC, IP, IH.

Anti-Integrin beta7 Antibody, clone TN114 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGB7 UniProt Number: P26010
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MAB2638
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IP, IHCAHmPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2638
      DescriptionAnti-Integrin beta7 Antibody, clone TN114
      Alternate Names
      • integrin, beta 7
      • integrin beta 7 subunit
      • Gut homing receptor beta subunit
      Background InformationIntegrin beta7 is an adhesion molecule belonging to the integrin beta chain family. It forms heterodimers with the alpha subunit, most notably the integrin alpha4 and alphaE subunits, functioning to mediate migration and homing of lymphocytes to the gut-associated lymphoid tissue (GALT). The heterodimer formed with alpha4, α4β7, is specifically involved in the homing and migration of lymphocytes to the gut, while αEβ7 is involved in the binding of T lymphocytes to epithelial cells and is induced by TGFβ1. Integrin beta7 has been observed in several different leukocyte lines.
      References
      Product Information
      FormatPurified
      Control
      • Human peripheral blood mononuclear cells (PBMC's).
      PresentationPurified armenian hamster monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin beta7 Antibody, clone TN114 is an antibody against Integrin beta7 for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Biological Information
      ImmunogenPurified human integrin beta7 protein.
      EpitopeUnknown
      CloneTN114
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostArmenian Hamster
      SpecificityThe antibody recognizes Integrin beta7.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITGB7
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

      SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICITY: Expressed in a variety of leukocyte lines.

      INDUCTION: Integrin alpha-E/beta-7 is induced by TGFB1.

      DOMAIN: Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.

      SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.

      Contains 1 VWFA domain.
      Molecular Weight~ 86 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in human PBMC's.

      Flow Cytometry Analysis: 1 µg/mL of this antibody detected Integrin beta7 on human PBMC's.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB2638 04053252288234

      Documentation

      Anti-Integrin beta7 Antibody, clone TN114 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Integrin beta7 Antibody, clone TN114 Certificates of Analysis

      TitleLot Number
      Anti-Integrin beta7, clone TN114 2476756
      Anti-Integrin beta7, clone TN114 2479803
      Anti-Integrin beta7, clone TN114 - 2437711 2437711
      Anti-Integrin beta7, clone TN114 - 1972818 1972818
      Anti-Integrin beta7, clone TN114 - 2541555 2541555
      Anti-Integrin beta7, clone TN114 - 3980281 3980281
      Anti-Integrin beta7, clone TN114 - NRG1736368 NRG1736368
      Anti-Integrin beta7, clone TN114 -2573685 2573685
      Anti-Integrin beta7, clone TN114 -2621733 2621733
      Anti-Integrin beta7, clone TN114 Monoclonal Antibody 2925720