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05-23-0101 Angiotensin II, Human - CAS 4474-91-3 - Calbiochem

Plays an important role in the regulation of blood pressure.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DRVYIHPF

Primary Target: adenylate cyclase activity
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05-23-0101
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4474-91-3C₅₀H₇₁N₁₃O₁₂

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          05-23-0101-5MGCN
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              Description
              OverviewPlays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.
              Catalogue Number05-23-0101
              Brand Family Calbiochem®
              SynonymsDRVYIHPF
              References
              ReferencesZhu, M., et al. 2000. J. Neurophysiol. 84, 2494.
              Natarajan, R., et al. 1999. Hypertension 33, 378.
              Mazzolai, L., et al. 1998. Hypertension 31, 1324.
              Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
              Ishida, M., et al. 1995. Circ. Res. 77, 1053.
              Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.
              Product Information
              CAS number4474-91-3
              ATP CompetitiveN
              FormWhite to off-white solid
              Hill FormulaC₅₀H₇₁N₁₃O₁₂
              Chemical formulaC₅₀H₇₁N₁₃O₁₂
              Hygroscopic Hygroscopic
              ReversibleN
              Sold on the basis of peptide contentY
              Quality LevelMQ100
              Applications
              Biological Information
              Primary Targetadenylate cyclase activity
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide ContentY
              Peptide SequenceH-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSBW2165000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              05-23-0101-1MGCN 04055977206906
              05-23-0101-25MGCN 04055977206913
              05-23-0101-5MGCN 04055977206920

              Documentation

              Angiotensin II, Human - CAS 4474-91-3 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Angiotensin II, Human - CAS 4474-91-3 - Calbiochem Certificates of Analysis

              TitleLot Number
              05-23-0101

              References

              Reference overview
              Zhu, M., et al. 2000. J. Neurophysiol. 84, 2494.
              Natarajan, R., et al. 1999. Hypertension 33, 378.
              Mazzolai, L., et al. 1998. Hypertension 31, 1324.
              Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
              Ishida, M., et al. 1995. Circ. Res. 77, 1053.
              Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision12-May-2008 JSW
              SynonymsDRVYIHPF
              DescriptionFunctions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.
              FormWhite to off-white solid
              CAS number4474-91-3
              RTECSBW2165000
              Chemical formulaC₅₀H₇₁N₁₃O₁₂
              Peptide SequenceH-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
              Purity≥98% by HPLC
              Solubility5% acetic acid (1 mg/ml) or H₂O (1 mg/ml)
              Storage -20°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
              Toxicity Standard Handling
              Merck USA index14 651
              ReferencesZhu, M., et al. 2000. J. Neurophysiol. 84, 2494.
              Natarajan, R., et al. 1999. Hypertension 33, 378.
              Mazzolai, L., et al. 1998. Hypertension 31, 1324.
              Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
              Ishida, M., et al. 1995. Circ. Res. 77, 1053.
              Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.