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676777 (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem

A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-Type Calcium Channel Blocker V

Primary Target: L-type Ca2+ channels
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676777
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
152-11-4C₂₇H₃₈N₂O₄ · HCl

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      Description
      OverviewA papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
      Catalogue Number676777
      Brand Family Calbiochem®
      SynonymsL-Type Calcium Channel Blocker V
      References
      ReferencesLonsberry, B.B., et al. 1994. Pharmacology 49, 23.
      Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
      Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
      Product Information
      CAS number152-11-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₇H₃₈N₂O₄ · HCl
      Chemical formulaC₂₇H₃₈N₂O₄ · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetL-type Ca2+ channels
      Purity≥99% by titration (with perchloric acid)
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYV8320000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676777-100MGCN 07790788052331

      Documentation

      (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      676777

      References

      Reference overview
      Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
      Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
      Janis, R., et al. 1987. Adv. Drug Res. 16, 309.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Title
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2008 RFH
      SynonymsL-Type Calcium Channel Blocker V
      DescriptionA derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca2+ through voltage-dependent Ca2+ channels in cell membranes. Blocks both activated and inactivated Ca2+ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.
      FormWhite solid
      CAS number152-11-4
      RTECSYV8320000
      Chemical formulaC₂₇H₃₈N₂O₄ · HCl
      Structure formulaStructure formula
      Purity≥99% by titration (with perchloric acid)
      SolubilityH₂O (70 mg/ml), Ethanol, or Methanol (50 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Toxicity Toxic
      Merck USA index14, 9950
      ReferencesLonsberry, B.B., et al. 1994. Pharmacology 49, 23.
      Shchepotin, I.B., et al. 1994. Anticancer Res. 14, 1027.
      Janis, R., et al. 1987. Adv. Drug Res. 16, 309.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
      		•