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565740 α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem

A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V

Primary Target: PKC
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565740
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
497259-23-1C₂₇H₃₀F₃N₃O₃

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565740-1MGCN
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      Description
      OverviewA cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.
      Catalogue Number565740
      Brand Family Calbiochem®
      Synonyms(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
      References
      ReferencesKozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.
      Product Information
      CAS number497259-23-1
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₂₇H₃₀F₃N₃O₃
      Chemical formulaC₂₇H₃₀F₃N₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target K<sub>i</sub>11.9 nM for activating PKCα
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565740-1MGCN 04055977267648

      Documentation

      α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      α-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      565740

      References

      Reference overview
      Kozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-September-2010 JSW
      Synonyms(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
      DescriptionA cell-permeable PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number497259-23-1
      Chemical formulaC₂₇H₃₀F₃N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Methanol (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364.