neuronal+signaling Search Results

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Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.
Acute and chronic neurodegeneration, for example, following brain injury or Alzheimer's disease, is characterized by programmed death of neuronal cells. The present study addresses the role and interaction of p53- and NF-kappaB-dependent mechanisms in delayed neurodegeneration following traumatic brain injury (TBI). After experi...
Document Type:

Reference

Product Catalog Number:

MAB377
Product Catalog Name:

Anti-NeuN Antibody, clone A60
Neuronal gap junction coupling is regulated by glutamate and plays critical role in cell death during neuronal injury.
In the mammalian CNS, excessive release of glutamate and overactivation of glutamate receptors are responsible for the secondary (delayed) neuronal death following neuronal injury, including ischemia, traumatic brain injury (TBI), and epilepsy. The coupling of neurons by gap junctions (electrical synapses) increases during neuro...
Document Type:

Reference

Product Catalog Number:

AB9209
Product Catalog Name:

Anti-Metabotropic Glutamate Receptor 2 Antibody
Neuronal injury induces microglial production of macrophage inflammatory protein-1α in rat corticostriatal slice cultures.
Chemokines are potent chemoattractants for immune and hematopoietic cells. In the central nervous system, chemokines play an important role in inflammatory responses through activation of infiltrating leukocytes and/or resident glial cells. We previously demonstrated that N-methyl-D-aspartate (NMDA)-evoked neuronal injury induce...
Document Type:

Reference

Product Catalog Number:

MAB377
Product Catalog Name:

Anti-NeuN Antibody, clone A60
Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1.
Perisynaptic astrocytes express important glutamate transporters, especially excitatory amino acid transporter 2 (EAAT2, rodent analog GLT1) to regulate extracellular glutamate levels and modulate synaptic activation. In this study, we investigated an exciting new pathway, the exosome-mediated transfer of microRNA (in particular...
Document Type:

Reference

Product Catalog Number:

MAB377
Product Catalog Name:

Anti-NeuN Antibody, clone A60
K252a suppresses neuronal cells apoptosis through inhibiting the translocation of bax to Mitochondria induced by the MLK3JNK signaling after transient global brain ischem ...
It is demonstrated that the c-Jun N-terminal kinase (JNK) signaling pathway plays a critical role in ischemic brain injury. Our previous studies have suggested that K252a can obviously inhibit JNK activation induced by ischemia/reperfusion in the vulnerable hippocampal CA1 subregion. Here, we further discussed the potential mech...
Document Type:

Reference

Product Catalog Number:

S7100
Product Catalog Name:

ApopTag® Peroxidase In Situ Apoptosis Detection Kit
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.
ATRX, a chromatin remodeling protein of the Snf2 family, participates in diverse cellular functions including regulation of gene expression and chromosome alignment during mitosis and meiosis. Mutations in the human gene cause alpha thalassemia mental retardation, X-linked (ATR-X) syndrome, a rare disorder characterized by sever...
Document Type:

Reference

Product Catalog Number:

AB1583
Product Catalog Name:

Anti-Neuropeptide Y Antibody
Neuronal nitric oxide synthase is dislocated in type I fibers of myalgic muscle but can recover with physical exercise training.
Trapezius myalgia is the most common type of chronic neck pain. While physical exercise reduces pain and improves muscle function, the underlying mechanisms remain unclear. Nitric oxide (NO) signaling is important in modulating cellular function, and a dysfunctional neuronal NO synthase (nNOS) may contribute to an ineffective mu...
Document Type:

Reference

Product Catalog Number:

Multiple
Product Catalog Name:

Multiple
Impaired neuronal insulin signaling precedes Aβ42 accumulation in female AβPPsw/PS1ΔE9 mice.
Reduced glucose utilization is likely to precede the onset of cognitive deficits in Alzheimer's disease (AD). Similar aberrant glucose metabolism can also be detected in the brain of several AD mouse models. Although the cause of this metabolic defect is not well understood, it could be related to impaired insulin signaling that...
Document Type:

Reference

Product Catalog Number:

AB1344
Product Catalog Name:

Anti-Glucose Transporter GLUT-3 Antibody, CT
Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and f ...
Tuberous sclerosis (TSC) is a hamartoma syndrome attributable to mutations in either TSC1 or TSC2 in which brain involvement causes epilepsy, mental retardation, and autism. We have reported recently (Meikle et al., 2007) a mouse neuronal model of TSC in which Tsc1 is ablated in most neurons during cortical development. We have...
Document Type:

Reference

Product Catalog Number:

AB980
Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation.
Myofibroblasts are implicated in pathological stromal responses associated with lung fibrosis. One prominent phenotypic marker of fully differentiated myofibroblasts is the polymerized, thick cytoplasmic filaments containing newly synthesized α-smooth muscle actin (α-SMA). These α-SMA-containing cytoplasmic filaments are importa...
Document Type:

Reference

Product Catalog Number:

05-537
Product Catalog Name:

Anti-FAK Antibody, clone 4.47

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