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14-195M c-Jun (1-169)-GST Protein, soluble, 250 µg

250 μg of c-Jun (1-169)-GST, soluble, N-terminal, Glutathione-Stransferase (GST) tagged, fusion protein, for use in Kinase Assays.

14-195M
250 µg  Also available in 100 μg size (cat#14-195) and in bulk (cat#14-195-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-195M
Brand Family Upstate
Trade Name
  • Upstate
Descriptionc-Jun (1-169)-GST Protein, soluble, 250 µg
OverviewN-terminal, Glutathione-Stransferase (GST) tagged, fusion protein
References
Product Information
Quality LevelMQ300
Applications
Application250 μg of c-Jun (1-169)-GST, soluble, N-terminal, Glutathione-Stransferase (GST) tagged, fusion protein, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourcecorresponding to truncated human c-Jun (1-169) expressed in E. coli
Entrez Gene Number
Entrez Gene SummaryThis gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Gene Symbol
  • JUN
  • AP1
  • p39
  • c-Jun
Protein Targetc-Jun
Purification MethodGlutathione agarose affinity chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
SIZE: 331 amino acids; 35676 Da
SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.
SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain.
Molecular Weight41 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of GST
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at -20 C
Packaging Information
Material Size250 µg
Material PackageAlso available in 100 μg size (cat#14-195) and in bulk (cat#14-195-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-195M 04053252924040

Documentation