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509892 Tetrabenazine, TBZ - CAS 58-46-8 - Calbiochem

A monoamine-depleting agent that blocks vesicular monoamine transporter 2 activity. Promotes late-stage differentiation of Pdx1 + pancreatic progenitor cells into Ngn3 + endocrine precursors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: VMAT2 Inhibitor, Xenazine

Primary Target: VMAT2
509892
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
58-46-8C₁₉H₂₇NO₃

Products

Catalogue NumberPackaging Qty/Pack
5098920001 Glass bottle 10 mg
Description
OverviewA cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number509892
Brand Family Calbiochem®
SynonymsVMAT2 Inhibitor, Xenazine
References
ReferencesSakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
Jankovic, J., et al. 1997. Neurobiology 48,1358.
Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.
Product Information
CAS number58-46-8
FormOff-white powder
Hill FormulaC₁₉H₂₇NO₃
Chemical formulaC₁₉H₂₇NO₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetVMAT2
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36-45

Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5098920001 04055977241174

Documentation

Tetrabenazine, TBZ - CAS 58-46-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Sakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
Jankovic, J., et al. 1997. Neurobiology 48,1358.
Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-May-2014 JSW
SynonymsVMAT2 Inhibitor, Xenazine
DescriptionA cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number58-46-8
Chemical formulaC₁₉H₂₇NO₃
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesSakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
Jankovic, J., et al. 1997. Neurobiology 48,1358.
Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.